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NIH/Other Sponsored Clinical Trials and Studies

Clinical studies/trials are important in finding more and better treatments. Participation in clinical studies or trials offers one way to help advance GI research. Here is a list of clinical studies, in adults and children, that are seeking participants. A description of the study purpose and contact information is included.


Functional Abdominal Pain

Seeking Families with Children with Recurrent Abdominal Pain

Purpose of study: This study will test a non-medicine treatment approach which, if successful, would substantially change the treatment of functional abdominal pain and potentially for a wide range of childhood medical problems where parental responses to symptoms affect child experiences of these events.

Sponsor: University of Washington

Collaborators: University of North Carolina and Mary Bridge Children's Hospital

Participation: Eligible children aged 7 to 12 who have experienced at least 3 episodes of unexplained abdominal pain over a 3 month period.

Locations: Chapel Hill, North Carolina; Seattle, Washington; and Tacoma, Washington

Contact: Sheri Ballard. Phone: 206-616-2358, Email:; Be sure to refer to this study by its identifier: NCT01620606

Verified February 2015

Cyclic Vomiting Syndrome (CVS)

Two Online Studies on Cyclic Vomiting Syndrome (CVS)

Purpose of study 1: A research study is being conducted in order to learn what the experiences are regarding two nutritional supplements, co-enzyme Q10 (also known as "Co-Q") and L-carnitine (Carnitor), and one medication, amitriptyline (Elavil), for the treatment of CVS. 

Sponsor: Eligible individuals of any age previously diagnosed with CVS

Participation: Eligible children aged 7 to 12 who have experienced at least 3 episodes of unexplained abdominal pain over a 3 month period.

Link: Click here to begin the survey

Purpose of study 2: CVSA is undertaking a formal process of educating Emergency Room physicians and para-professionals about CVS. They are asking for your participation in a brief survey in order to help plan this educational approach. 

Sponsor: Cyclic Vomiting Syndrome Association (CVSA) and Children's Hospital of Wisconsin

Participation: Eligible individuals of any age who have ever visited the emergency room for the care of CVS either as a patient or as a caregiver to a patient

Link: Click here to begin the survey

Verified February 2015


NIH Gastroparesis Clinical Research Consortium  (GpCRC) Registry

Purpose of study: The GpCRC is recruiting patients for their gastroparesis registry. Individuals with gastroparesis who sign up for the registry may be contacted about participating in trials or surveys about gastroparesis. The GpCRC is a network of medical centers, sponsored by the National Institutes of Health (NIH), Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), established to improve our understanding of the cause and natural course of gastroparesis and to advance the diagnosis and treatment of this disorder.

Sponsor: NIDDK

Participation: Eligible male and female individuals aged 18 and older who have been previously diagnosed with gastroparesis and delayed gastric emptying

Contacts & Registration: See the listing for information on locations and contacts.

Verified April 2015

Rare Genetic Diseases

Recruiting Individuals with Rare Genetic Disorders

Purpose of study: In an effort to help researchers working to understand gastrointestinal motility diseases like mitochondrial nueorgastrointestinal encephalopathy, blood samples and clinical data from individuals with rare genetic diseases are being collected. The samples are made anonymous and shared with scientists to use in their research for treatments and causes. Families living outside the US are also welcome to donate a sample to the repository.

Sponsors: The National Institute of General Medical Sciences (NIGMS) Human Genetic Cell Repository Program and Coriell Institute for Medical Research

Participation: Eligible individuals with an inherited genetic disease or chromosomal abnormality

Contacts: Families who want to participate in this research effort can can read more about the Repository and donation process here, or can contact the NIGMS Human Genetic Cell Repository genetic counselor, Tara Schmidlen, MS, CGC, for postage-paid sample collection kits and the necessary paperwork: Phone: 856-757-4822, Email:

Verified February 2015

Hirschsprung's Disease

Participants Sought for Genetic Study of Hirschsprung's Disease

Purpose of study: Dr. Aravinda Chakravarti's laboratory at Johns Hopkins University has been investigating the genetics of Hirschsprung's disease for more than twenty years. The purpose of this study is to continue the search for genes involved in Hirschsprung's disease and to further characterize the known genes and the interactions between them. The study will hopefully lead to a better understanding of the genetics of Hirschsprung's disease and improve diagnosis, treatment, and genetic counseling.

Study volunteers and their parents (as available) are asked to complete a medical/family history questionnaire, provide access to select medical records, and submit to blood or cheek swab/saliva samples. If interested, a kit containing all the materials necessary to participate can be sent at no cost to the volunteer.

Sponsor: Johns Hopkins University

Participation: Eligible individuals with Hirschsprung's disease and their family members.

Contact: Courtney Berrios. Phone: 410-502-7541, Email: You can also visit our study website at:

Verified February 2015

Irritable Bowel Syndrome (IBS)

Online Survey on Effective Doctor-Patient Relationships

Purpose of study: IFFGD, together with the University of Michigan and the Drossman Center for Education and Practice of Biopsychosocial Care, is seeking people with irritable bowel syndrome (IBS) to participate in the research study. This online survey aims to help patients and physicians form an effective therapeutic relationship.

About the Study: The study involves completing an online questionnaire about the relationships between patients and their doctors. It shouldn’t take more than 30 minutes.

Your participation in this survey will help training physicians provide better care in the future for all patients.

Sponsors: University of Michigan and the Drossman Center for Education and Practice of Biopsychosocial Care

Participation: If you are over 18 years old, live in the US or Canada, and have seen a gastroenterologist in the last 6 months, you may be eligible to participate.

How to Begin the Study: Please visit this link for more information and to begin with some preliminary eligibility questions.

As thanks for your participation, all who complete the study will be entered into a raffle to win one of thirty $100 Visa gift cards. The winning participants will be notified by email after the study has ended.

Contact: If you have any questions about the study, please contact the study coordinator, Lina Nahlawi, at

Added November 2014

Participants Sought for Study on Complementary Approaches to the Treatment of IBS

Purpose of study: The purpose of this study is to find a complementary treatment to help Irritable Bowel Syndrome (IBS) patients in need of relief.

About The Study: The length of this study will be three weeks long, with a short online intervention everyday to help individuals deal with their body’s reactions to their environments. Participants will have additional surveys to assess their overall state at the beginning of the study, at the end of the three week intervention, and again at six weeks for a follow-up.

Participation: Eligible individuals between the ages of 18 – 65 years of age who are experiencing pain or discomfort associated with their gut. Cannot be smokers or have an inflammatory bowel disease.

How to Sign Up:

There will be a $15 Target gift card for first 30 participants upon completion of study.

Study Contact: Jenna N. Ray,  Health Psychologist. Phone: (919) 257 – 7291, Email:

Added September 2014

Seeking IBS Patients and Their Partners

Purpose of study: IBS patients know that their intimate relationships can have an effect on how they are feeling. However, it is not known whether agreement or disagreement regarding issues such as cause of IBS, beliefs about illness, harmony in relationship may have an effect on IBS symptoms. This is an important question that may affect the way IBS is treated.

About the study: Our study requires patients to complete 5 brief questionnaires and partners to complete 3 brief questionnaires. Patients and partners will be contacted separately and results will be strictly confidential with no way of identifying subjects.

Contact: Please contact, and links to a secure survey site will be sent individually to both patient and partner, with instructions. From that point on, no identifying information will be stored.

Verified February 2015


Online Survey Aimed at Understanding Episodes of IBS

Purpose of study:  This online survey has been constructed in order to compile written reports of IBS episodes and help the researchers gain a better understanding of the symptoms and experiences people have during an IBS episode.

About the study: Have you been diagnosed with IBS? If so, you are eligible to help out with a one-time online survey that may take up to 20 minutes to complete. This survey is completely confidential and you will not be asked any identifying information.

Sponsor: University of North Carolina – Chapel Hill and the Drossman Center for Education and Practice of Biopsychosocial Care

To participate: Click here to begin.

Study Contact: Dr. Stephan Weinland. Phone: (919) 843 – 4422, Email:

Verified March 2015

Online Survey on Symptoms in IBS

Purpose of study:  One of the most important questions for individual patients with irritable bowel syndrome (IBS) is how long the symptoms will continue. A number of factors are thought to be important in determining recovery from IBS but so far studies have not been big enough to be certain of the results. The aim of this world-wide survey will be to gather together the experience of a large number of patients with irritable bowel syndrome, both those in whom it has begun with an infection and those in whom it has not. By comparing these we will be able to understand more about both conditions.

About the study: This is a web-based survey designed to help learn more about irritable bowel syndrome in order that physicians might better plan treatments and management. Of particular interest is how symptoms develop over time. The study is multilingual and is currently available in nine languages.

Sponsor: European Gastroenterology Federation

To participate: Go to and click on your language of choice to complete the simple online questionnaire.

Verified February 2015

Last modified on April 24, 2015 at 09:52:46 AM