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NIH/Other Sponsored Clinical Trials and Studies

Clinical studies/trials are important in finding more and better treatments. Participation in clinical studies or trials offers one way to help advance GI research. Here is a list of clinical studies, in adults and children, that are seeking participants. A description of the study purpose and contact information is included.

Abdominal Pain 

Seattle, WA

Parents: Does your child or teen have frequent stomachaches?

Research at Children's Hospital Division of Gastroenterology (Seattle) and the University of Washington Children’s Hospital (Seattle) and the University of Washington are looking for volunteers to take part in a research study that looks at ways to help kids who have stomachaches with no known physical cause. If your child or teen age 8 to 16 years has stomach pain that interferes with daily activities, we want you to participate!

Both you and your child must take part in the study. To see if your child is eligible, we will ask you a few screening questions and discuss your child’s medical history over the phone. If eligible, you and your child will come to Children’s Hospital for three visits scheduled at times that work for you. At each hour-long visit, you and your child will talk to a counselor or social worker and learn ways to deal with stomachaches. No medicines are used in this study. You and your child will also be asked to complete a survey five times during the year. You will receive $30 for finishing each survey ($150 total by the end of the study).

The study, called the Recurrent Abdominal Pain (RAP) study, is funded by the National Institutes of Health and has been approved by Children’s Institutional Review Board. If you are interested in joining the study or would like to refer a child, please visit our website at www.rapstudy.org or call (206) 616-2358.

Verified August 2013

Seattle, WA

Research at Children's Hospital Division of Gastroenterology (Seattle) and the University of Washington

Volunteers from throughout the Puget Sound region are needed to take part in a research study. The study is looking at interventions to help children with Recurrent Abdominal Pain. We are studying children ages 8-16 who experience frequent stomachaches that interfere with their daily activities but have no known physical cause. We are asking both the child and parent to take part in this study.

The research involves a 10-minute telephone interview with the parent by the Project Director and examination of medical records by a Pediatric Gastroenterologist to see if the child is eligible. If eligible, the parent and child will attend three one-hour intervention sessions with a trained clinician at Children's Hospital over the course of two to three weeks. Visits will be arranged at times convenient to families.

At the visits, parent and child will learn information about coping with stomachaches. Parent and child will also be asked to complete questionnaires five times over the course of one year; these take approximately 60-90 minutes to fill out each time. Families will receive $30 for completing each set of questionnaires ($150 total by the end of the study).

The Principal Investigator for this project is Dr. Rona L. Levy, Professor, UW School of Social Work, (206) 543-5917. The study is funded by the National Institutes of Health and has been approved by Children's Hospital's Institutional Review Board (IRB). If you are interested in taking part in this research study or would like to refer a child to the study, please call the Project Director at (206) 616-2358. 

Verified August 2013

Cyclic Vomiting Syndrome (CVS)

Internet/Online

A research study is being conducted by Richard G. Boles, M.D. from the Department of Medical Genetics at CHLA in order to learn what the experiences are regarding two nutritional supplements, co-enzyme Q10 (also known as "Co-Q") and L-carnitine (Carnitor), and one medication, amitriptyline (Elavil), for the treatment of cyclic vomiting syndrome (CVS). Find out more and access online survey here.

The Cyclic Vomiting Syndrome Association (CVSA) is undertaking a formal process of educating Emergency Room physicians and para-professionals about Cyclic Vomiting Syndrome (CVS). They are asking for your participation in a brief survey via this link in order to help plan this educational approach, which is under the project leadership of  B.U.K. Li, M.D., Children's Hospital of WI. 

Verified August 2013

 

Gastroparesis

NIH Gastroparesis Clinical Research Consortium  (GpCRC)

The GpCRC is recruiting patients for their gastroparesis registry. Individuals with gastroparesis who sign up for the registry may be contacted about participating in trials or surveys about gastroparesis. The GpCRC is a network of medical centers, sponsored by the National Institutes of Health (NIH), Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), established to improve our understanding of the cause and natural course of gastroparesis and to advance the diagnosis and treatment of this disorder.

Contact

James Tonascia, PhD at 410-955-3704; jtonasci@jhsph.edu

Aynur Unalp-Arida, MD, PhD at 410-614-4851; aunalp@jhsph.edu


Verified August 2013

Gainesville, FL

A study at the University of Florida is looking at the comparative effectiveness of two drugs, Azithromycin (AZI) and Erythromycin in the treatment of gastroparesis. The effectiveness of Erythromycin is currently known in the treatment of gastroparesis patients, however in susceptible patients is associated with adverse events. Azithromycin is an antibiotic with fewer known side effects.

The study is open to men and women aged 18 to 65 presenting to gastroenterology motility specialty clinics at the University of Florida, who meet the clinical and radiologic diagnostic criteria for diagnosis of gastroparesis.

Contact

Lasheaka V. McClellan at 352-392-6293; lasheaka.mcclellan@medicine.ufl.edu

Cheryl Curington, BS at 352-392-6293; cheryl.curington@medicine.ufl.edu 

req. ver. August 2013

 

Genetic Motility Disorders

Worldwide

The National Institute of General Medical Sciences (NIGMS) Human Genetic Cell Repository at the non-profit Coriell Institute for Medical Research is seeking blood samples from from individuals with rare genetic diseases.

In an effort to help researchers working to understand genetic gastrointestinal motility diseases like mitochondrial neurogastrointestinal encephalopathy (MNGIE), the Repository is collecting blood samples and clinical data from individuals with rare genetic diseases. The samples are made anonymous and shared with scientists to use in their research for treatments and causes. Families living outside of the United States are also welcome to donate a sample to the repository.

Families who want to participate in this research effort can can read more about the Repository and donation process here, or can contact the NIGMS Human Genetic Cell Repository genetic counselor, Tara Schmidlen, for postage-paid sample collection kits and the necessary paperwork:

Tara J. Schmidlen, MS, CGC
Certified Genetic Counselor
Coriell Institute for Medical Research
403 Haddon Avenue
Camden, NJ 08103
tschmidl@coriell.org
phone: 856-757-4822

Added Sept 2014

 

Hirschsprung's Disease

Baltimore, MD

Dr. Aravinda Chakravarti’s laboratory at Johns Hopkins University has been investigating the genetics of Hirschsprung disease for more than twenty years. The purpose of our study is to continue the search for genes involved in Hirschsprung disease and to further characterize the known genes and the interactions between them. Our study will hopefully lead to a better understanding of the genetics of Hirschsprung disease and, further down the road, improved diagnosis, treatment, and genetic counseling.

Our study will hopefully lead to a better understanding of the genetics of HSCR and, further down the road, improved diagnosis, treatment, and genetic counseling.

Anyone with Hirschsprung disease and their family members may join the study. We ask study volunteers to complete a medical/family history questionnaire, provide access to some medical records, and to submit blood or cheek swab/saliva samples from the individual(s) affected with Hirschsprung disease and his/her parents (if available).

If you are interested, a kit containing all the materials necessary to participate can be sent to you. There will be no cost to you.

For more information please contact the study coordinator, Courtney Berrios, at 410-502-7541 or hirschsprung@igm.jhmi.edu.

You can also visit our study website at: https://aravindachakravartilab.org/pro/Hirschsprung_Study.html.

Verified August 2013

 

Irritable Bowel Syndrome (IBS)

Internet/Online

Online IBS Intervention

Purpose: The purpose of this study is to find a complementary treatment to help Irritable Bowel Syndrome patients in need of relief.

Who May Participate:

  • Individuals experiencing pain or discomfort associated with their gut
  • Cannot be smokers or have an inflammatory bowel disease
  • Must be between the ages of 18 – 65 years

About The Study: The length of this study will be three weeks long, with a short online intervention everyday to help individuals deal with their body’s reactions to their environments. Participants will have additional surveys to assess their overall state at the beginning of the study, at the end of the three week intervention, and again at six weeks for a follow-up.

How to Sign Up: http://bit.ly/IBS_study

There will be a $15 Target gift card for first 30 participants upon completion of study.

Study Contact: Jenna N. Ray,  Health Psychologist
(919) 257 – 7291
jray51@uncc.edu

Added September 2014

A research study of IBS patients and their partners.

IBS patients know that their intimate relationships can have an effect on how they are feeling. However, it is not known whether agreement or disagreement regarding issues such as cause of IBS, beliefs about illness, harmony in relationship may have an effect on IBS symptoms. This is an important question that may affect the way IBS is treated.

Our study requires patients to complete 5 brief questionnaires and partners to complete 3 brief questionnaires. Patients and partners will be contacted separately and results will be strictly confidential with no way of identifying subjects.

If patient and partner are willing to participate, please contact: mindbodydigest@gmail.com, and links to a secure survey site will be sent individually to both patient and partner, with instructions. From that point on, no identifying information will be stored.

*If you wish to participate, please have patient and partner reply separately and indicate BOTH the name of the name of the patient and the name of the partner (and please clarify who is the patient and who is the partner).

Drs. Charles and Mary-Joan Gerson, The Mind-Body Digestive Center

Added August 2014

 

Chapel Hill, NC

 

Healthy Controls Needed for Research Study

We are conducting a research study investigating a broad range of factors that may cause or influence IBS. We are looking for subjects without IBS or any other gastrointestinal (stomach or bowel) symptoms to participate.

Contact: Research Nurse, Lenore Keck, RN, (919) 966.8329, akeck@med.unc.edu 

Participation

  • Must be 18 years or older.
  • Must have not experienced any gastrointestinal symptoms within the last 3 months.
  • Must fill out various health questionnaires & physiological testing
  • Involves one 4 hour visit to the Clinical and Translational Research Center at UNC Hospital.

For more information on how to sign up please visit: Please visit www.uncmedresearch.com/ibsstudy or call toll-free 1-866-227-0067. 

Verified August 2013

Chicago, IL

Center for Psychosocial Research in GI, Feinberg School of Medicine, Northwestern University, Chicago IL is seeking volunteers for an Irritable Bowel Syndrome Outcome Study (IBSOS).

The Irritable Bowel Syndrome Outcome Study (IBSOS) is a seven-year, multi-site clinical trial to test the efficacy of a behavioral self-management treatment for irritable bowel syndrome (IBS) funded by the NIH. The long-term goal of the project is to develop an effective, self-administered behavioral treatment program that can enhance the quality of patient care, improve clinical outcomes, and decrease the economic and personal costs of one of the most prevalent and intractable GI disorders.

This is a multi-center study involving 480 subjects, with 240 subjects participating here at Northwestern University and 240 subjects participating at the University of Buffalo.

Study participants are assigned to 1 of 3 non-drug treatment groups. One group will undergo treatment that will involve 10 weekly clinic visits, while the other 2 groups will undergo treatment with 4 clinic visits and 2 brief telephone calls over the same 10 week period. There follow-up period consisting of 5 visits over the year following treatment.

Contact:
IBSOS Study Coordinator, Phone: 312-695-6729
E-mail: IBSOS@northwestern.edu
Website: www.cprgi.org

Verified August 2013

Internet/Online 

IBS survey: Impact of IBS on Daily Life

Researchers at Northwestern University are seeking participants with IBS to complete a 20 minute online survey about the impact of IBS on daily life and well-being.

You are eligible if:

  • You are between the ages of 18-70, and
  • You have IBS

If you are interested in completing this survey, please click the link: https://adobeformscentral.com/?f=wGDa7rnWSs0TipMX0yWkIA#

Thank you for your interest!

Updated July 2013

IBS survey: Defining the Clinical Features and Prognosis of Post Infectious and other IBS groups.

The European Gastroenterology Federation is undertaking a survey of patients with irritable bowel syndrome. This is a web based survey designed to help learn more about irritable bowel syndrome in order that physicians might better plan treatments and management. Of particular interest is how symptoms develop over time. The study is multilingual and is currently available in nine languages. To participate, go to www.postinfectious-ibs.eu and click on your language of choice to complete the simple online questionnaire.

Verified August 2013

Los Angeles, CA

Therapeutic Movement as a Complementary Treatment for Irritable Bowel Syndrome (IBS) - UCLA

Participate in a UCLA research study of the benefits of Therapeutic Movement (Therapeutic Yoga & Therapeutic Walking) for Irritable Bowel Syndrome (IBS).

You must be between 18 and 65 years of age and living in the Los Angeles area. If eligible, you will be able to attend 16 Movement Classes, free of charge.

Groups will be held at UCLA on weekday evenings and weekend afternoons. Each session will be around 1 hour in length. The study will offer 16 sessions of their yoga or walking program as a part of participation in the study. The aim is to evaluate if these programs assist with the symptoms of IBS. 

Contact: Phone 310-825-6475 for more information.

Study conducted by David Shapiro, PhD, and Bruce Naliboff, PhD, UCLA Department of Psychiatry. 

Verfied August 2013

New York, NY

IBS: Attachment style, catastrophizing and negative pain beliefs

This is an international study of IBS patients in ten different sites around the globe. It is directed by the Mind-Body Digestive Center in New York City. Patients are asked to complete a set of four questionnaires at the time of their initial visit, recorded anonymously without any patient identification.

The goal of this study is to see if there are any universal patterns, or any intra-country differences in the way that the psycho-social measures above correlate with the severity of symptoms in IBS patients.

Contact: The Mind-Body Digestive Center, directed by Charles Gerson, M.D. and Mary-Jane Gerson, Ph.D.
Telephone: 212-712-0494, Fax: 212-787-0983

Verified Aug 2013

 

 

 

Last modified on September 11, 2014 at 01:03:01 PM