IFFGD Competitive Grants Awarded
IBS Susceptibility Genotypes and Gastroenteritis Exposure in the Developing Nation Setting
Primary Investigator: Douglas R. Morgan, MD, Associate Professor of Medicine, University of North Carolina at Chapel Hill. multi-year
Aims: To explore the IBS susceptibility genotypes in a general population of Central America using a population surveillance system; to determine the association of microbial factors with IBS in the developing nation environment, wherein the majority of the population has been exposed to bacterial gastroenteritis and gastrointestinal infections are recurrent.
Role of Eosinophil Activation on Mucosal Inflammation in Diarrhea-IBS Patients
Primary Investigator: Javier Santos, MD, PhD, Senior Staff Physician, Hospital General Universitario Valle de Hebron. 1-year
Aims: To determine whether intestinal eosinophils are key to the development and perpetuation of mucosal inflammation in the jejunum of IBS patients and to characterize molecular mechanisms involved.
Maternally Inherited mtDNA Sequence Variants in Functional Disorders
Primary Investigator: Miranda A.L. Van Tilburg, PhD, Research Assistant Professor, University of North Carolina at Chapel Hill. multi-year
Aims: To determine the presence and degree of maternal inheritance of functional disorders in IBS; to determine if specific polymorphisms predispose towards the development of IBS and other functional disorders.
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